Dr. Amla Chopra
Assistant Professor
Dayalbagh Educational Institute (Deemed to be University)
Dr. Amla Chopra, Zoology, major interest is in the development of non-invasive vaccination strategies. The laboratory has been working on deformable biodegradable nanoparticles mediated non-invasive delivery of drugs and vaccines.The laboratory has shown the effect of higher order function like meditation on the general health assigning “immune status” as a “neural correlate” establishing correlation between high order signaling to brain affecting the physiological status of the human body. Chopra et al. Levels of Consciousness and immune-strength profile: A Correlation. Study of tubulin heterodimer and its function in quantum superposition and entanglement in microtubule mediated signal processing.
Research Interests: Elucidation of mechanism of transport of drugs/antigens associated with nanoparticles across intact mammalian skin. Development of non-invasive vaccines with enhancing immune activity against Th1 as well as Th2 antigens. Development of skin explant assay system to test various adjuvant molecules in ex vivo cultures that may be extrapolated in vivo. . Development of DNA Cancer vaccines by constructing allogeneic fibroblast and dendritic cells. Study of tubulin heterodimer and its function in quantum superposition and entanglement in microtubule mediated signal processing.
Grants: 1996-2000: Under CSIR encouragement drive of Academic-Industry Interaction, grant of 14.5, 00.00 DM was awarded by IDEA-GmbH . Development of non-invasive vaccine against lethal challenge of tetanus toxin in mice. 2009-2013: Awarded grant of 82.33 lacs by Department of Biotechnology, entitled "Non-Invasive delivery of drugs/vaccines across intact mammalian skin using transfersome (50-100 nm) with combination of adjuvants: mechanism/s involved in transport of transfersome associated antigens”.
Best 05 publications
1. Kumar G, Sharma N, Gupta P, Joshi B, Gupta UD, Cevc G, Chopra Amla. Improved protection against tuberculosis after boosting the BCG-primed mice with subunit Ag 85a delivered through intact skin with deformable vesicles. European Journal of Pharmaceutical Sciences. 2016 Jan 20;82:11-20.
2. Amla Chopra and Gregor Cevc. Non-invasive, epicutaneous immunisation with toxoid in deformable vesicles protects mice against tetanus, chiefly owing to a Th2 response. Eur J Pharmceutical Sci 2014; 56, 55-64.
3. Amla Chopra nee Paul, Gregor Cevc and Bimal K. Bachhawat. (1998). Transdermal immunization with an integral membrane component, gap junction protein, by means of ultradeformable drug carriers, Transfersomes. Vaccine16: 188-95.
4. Andreas Schätzlein, Gregor Cevc, Amla Chopra nee Paul, Gabriel Blume. Ultraflexible vesicles, transfersomes TM, as transdermal drug carriers for peptides and proteins. Journal of Controlled Release. 1997;46(1-2):179-80.
5. Amla Chopra nee Paul, Gregor Cevc and Bimal K. Bachhawat. (1995). Transdermal immunisation with large proteins by means of ultradeformable drug carriers. Eur. J. Immunol. (1995) 25: 3521-3524.
Patents:
Patents and Publications: Amla Chopra (nee Paul) and Gregor Cevc . Title: Noninvasive vaccination through the skin. European Patent (2002) EP1031346B1. Application Number: EP1999000101479 and Gregor Cevc, Amla Chopra (nee Paul) and Juliane Steiber. Title:Transnasal transport/immunisation with highly adaptable carriers. European Patent (2002) EP1031347B1: Application Number: EP1999000101480.